Funding Timeline
A chronological record of grants and contracts that have supported the Networked Neuroprosthesis (NNP) System and its open-source successor, COSMIIC.
COSMIIC tSNIP to Treat Chronic Knee Pain
Michael Moffitt, PhD
Development of a light-delivery cuff and a module to control it, designed to apply tSNIP (transient selective neural inhibition via photobiomodulation) as a treatment for chronic knee pain. They will study the device in sheep to characterize its analgesic efficacy.
The COSMIIC Open-Source Neuromodulation Ecosystem
Michael J Fu, PhD
Growth of the COSMIIC ecosystem through onboarding and organizational initiatives
Exploratory Trial of the RESTORES (Revolutionary Electrical Stimulation Technology to Optimize Recovery of Everyone with Spinal Cord Injury) System
Michael J Fu, PhD
Years 1–3: customize and validate a multi-function COSMIIC system for arm/hand, trunk, lower-extremity, and bladder/bowel function. Years 4–5: first-in-human coordinated multi-function clinical study.
Preparing for a clinical trial to implement a fully implanted neuroprosthesis to restore walking after partial paralysis
Gilles Pinault
Stage 1 translational research award to prepare for an Early Feasibility Study IDE for the COSMIIC System in Veterans with partial paralysis (stroke, MS, incomplete SCI) to restore community walking. Investigating approach to MRI-conditional status for COSMIIC System
Enhancing Walking and Independence After Incomplete SCI with a Fully Implanted Neuroprosthesis
Nathan Makowski, PhD
First-in-Human study using the COSMIIC System for studying restoration of standing and walking in people with incomplete spinal cord injury
Cleveland Open Source Modular Implant Innovators Community (COSMIIC)
Kevin L. Kilgore, PhD; MPI: Cindy Chestek, PhD (Univ. of Michigan), Brian Smith, BSc (CWRU)
Establishes the Network Neuroprosthesis system as open-source and creates a community of early adopters.
Augmenting Implanted Neuroprosthetics with Targeted Health Monitoring for Spinal Cord Injury – the LIFELINE
Kevin L. Kilgore, PhD
Developing health monitoring capacities in a new NNP system module to provide advanced warning regarding the top causes of increased mortality in individuals with SCI
Restoration of Grasp and Reach in Cervical Spinal Cord Injury
MPI: Kevin L. Kilgore, PhD; Anne M. Bryden, PhD; Megan Moynahan, MS
Funded through the NIH Bioengineering “CREATE” mechanism.
Enhanced Modular Neuroprosthesis for the Restoration of Function in Neurological Injury or Disease
Kevin L. Kilgore, PhD
Phase 2 Study of a Networked Neuroprosthesis for Grasp, Reach, and Trunk Function in Cervical Spinal Cord Injury
Kevin L. Kilgore, PhD
Originally funded through 8/31/2020; extended through 8/31/2025.
IFR Commercialization Partnership
P. Hunter Peckham, PhD
Seed funding to commercialize fully implantable neuroprosthetics through the Institute for Functional Restoration (IFR), in partnership with Synapse Biomedical Inc.
Whole-body Neuroprosthetic Approach for Incomplete Cervical Spinal Cord Injury
Kevin L. Kilgore, PhD
The goal of this project was develop a comprehensive screening assessment strategy for the implementation of neuroprosthetics for incomplete cervical SCI subjects, implant in eight incomplete SCI subjects, evaluate the resulting functional outcomes, and gain preliminary data regarding home use and possible strengthening and recovery of function.
Efficacy Study of a Fully Implanted Neuroprosthesis for Functional Benefit to Individuals with Tetraplegia.
P. Hunter Peckham, PhD
Commercializing a neurostimulation technology platform designed to treat multiple clinical indications
State of Ohio commercialization co-funding for the NNP platform awarded to CWRU, NDI Medical, SPR Therapeutics, and Valtronic Technologies.
Development of Networked Implantable Neuroprostheses
P. Hunter Peckham, PhD (Co-I: Kevin L. Kilgore, PhD)
BRP Renewal through NIBIB and NICHD. Feasibility clinical study of the upper extremity Networked Neuroprosthetic System to demonstrate efficacy in providing grasp and reach for individuals with cervical level spinal cord injury.
Multi-functional Neuroprosthetic Systems for Restoration of Motor Function
P. Hunter Peckham, PhD
Finalize the key components of a holistic neuroprosthetic approach that includes the technology, regulatory approvals, surgical installation, outcome assessment and overall implementation
Development of Networked Implantable Neuroprostheses
P. Hunter Peckham, PhD
BRP Renewal through NIBIB
Development of Networked Implantable Neuroprostheses
P. Hunter Peckham, PhD
Founding award for the Networked Neuroprosthesis concept. Bioengineering Research Partnership (BRP)
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